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Saturday
Jun012013

Lysine

"Lysine (abbreviated as Lys or K)[1] is an α-amino acid with the chemical  formula HO2CCH(NH2)(CH2)4NH2. It is an essential amino acidfor humans. Lysine's codons are AAA and AAG."

"Lysine is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base incatalysis. (The ε-amino group (NH3+) is attached to the fifth carbon beginning from the α-carbon, which is attached to the carboxyl (C=OOH) group.[2])"

"Common posttranslational modifications include methylation of the ε-amino group, giving methyl-dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications at lysine residues include acetylation and ubiquitinationCollagencontains hydroxylysine, which is derived from lysine by lysyl hydroxylaseO-Glycosylation of hydroxylysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell."


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